Deubiquitinases as potential anti-cancer targets for gold(III) complexes.
نویسندگان
چکیده
A panel of [Au(III)(C^N)(R2NCS2)](+) (HC^N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 49 45 شماره
صفحات -
تاریخ انتشار 2013